Guinea pigs, and many of the small exotic mammal pets we have, show vague signs of being sick when they develop a disease condition. Your guinea pig is showing classic signs of illness. No matter what is wrong with a guinea pig — be it a kidney infection, abnormal tooth growth, disease of the liver, or even an abscess — the only signs your guinea pig may show is not eating or drinking. This eventually causes your guinea pig to become even sicker, there is weight loss and sometimes the liver becomes affected, too. Unfortunately, there are no home remedies that can help your guinea pig if offering his favorite foods and water do not help him start eating again. My suggestion is to get him to a veterinarian as soon as you can. One who is familiar with guinea pig medicine and can get a diagnosis for you. As soon as you have a diagnosis, you can get your guinea pig back on the road to health. Want to know more about the health and wellness of your guinea pig? Check out: Guinea Pig Body Language Common Guinea Pig Health Issues Guinea Pig Seems To Have A Cold,Q: